Paneth cell α-defensins in enteric innate immunity
نویسندگان
چکیده
منابع مشابه
Paneth cell α-defensins and enteric microbiota in health and disease
Antimicrobial peptides are major effectors of innate immunity of multicellular organisms including humans and play a critical role in host defense, and their importance is widely recognized. The epithelium of the intestine is the largest surface area exposed to the outer environment, including pathogens, toxins and foods. The Paneth cell lineage of intestinal epithelial cells produces and secre...
متن کاملInnate immunity includes defensins
COMMENTARY We would like to comment on the comprehensive review of Karantanos and Gazouli in Annals of Gastroenterology [1] about genetics and innate immunity in inflammatory bowel disease (IBD). The authors appreciate the important role of innate immune sensing and the production of antimicrobial peptides in maintaining the integrity of the mucosal barrier. Pertinent studies on the subject are...
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Correspondence to: Professor Y R Mahida, Institute of Infection, Immunity, and Inflammation, C Floor, West Block, Queen’s Medical Centre, Nottingham NG7 2UH, UK; Yash.Mahida@ Nottingham.ac.uk _________________________ I n this article, we discuss the current understanding of how the intestinal mucosa may exert control over luminal bacteria, and how intestinal inflammation could ensue when this ...
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Small intestinal Paneth cells secrete α-defensin peptides, termed cryptdins (Crps) in mice, into the intestinal lumen, where they confer immunity to oral infections and define the composition of the ileal microbiota. In these studies, facultative bacteria maintained under aerobic or anaerobic conditions displayed differential sensitivities to mouse α-defensins under in vitro assay conditions. R...
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*Department of Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616; †Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI 53226; ‡Department of Biological Sciences, California State University, Los Angeles, CA 90032; §Department of Medicine, David Geffen School of Medicine, University of California, Los Angele...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2011
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-011-0714-6